The Ministry of Health in Benin has used an innovative approach that combines modeling with qualitative and quantitative assessment to identify the strategic direction for optimizing the vaccine supply chain. These guidelines have been implemented for demonstration purposes in the Comé health area with the support of the Agence de Médecine Préventive (AMP) via the LOGIVAC project. The activities carried out since 2013 have had a positive impact on the performance of the health system, in particular by ensuring better availability of quality vaccines in health facilities