Dear Erida
It´s clear the protocol was written in 2003 but I think this study creates a little confusion because the graphics results in ANNEX 8 are out of the range of temperatures. I guess that the vaccine carriers and insulated containers didn´t have PIS.
The MKT is the tool used by laboratories, when whatever vaccine come to our warehouse, I turn off the dataloggers and when I read them on PC, the MKT is the more important value to decide the acceptation or not. But this MKT is not easy to following using in Province, district and health care because we have 26 differents vaccines, some freeze-dried, others liquid and in differents amounts, i.e. 0.5 ml, 5 ml, 1.5 ml, 1 ml etc. with different activation energy. In those links of the chain we used cold box and vaccine carriers with PQS (mandatory). If the icepacks are in the beginning of the heat transfer by latent heat the PQS garantee us the perfect condition of all vaccines inside it.
I thank the laboratories like Serum (VOP) and Pfizer (Prevenar) the VVM in its vaccines, it´s a great helpful.