Article de revue
An HIV vaccine: Mapping uncharted territory
Scaling up access to antiretroviral therapy and proven approaches to HIV prevention potentially could control the HIV/AIDS pandemic and reduce it to a low level of endemicity. However, a safe and effective HIV vaccine would help reach this goal more quickly and in a more sustained way.
The scientific quest for an HIV vaccine spans nearly 3 decades and has taken multiple pathways, including attempts to induce antibody responses, T-cell responses, or combinations of both. These efforts have included human efficacy trials of monomeric HIV envelope glycoproteins, vectors containing inserts of HIV genes expressing envelope and other viral proteins, and prime-boost regimens that combine both approaches.
Auteurs
Langues
- Anglais
Année de publication
2016
Journal
JAMA
Volume
2
Type
Article de revue
Catégories
- Vaccins et dispositifs d'administration
Maladies
- VIH-SIDA
Mots-clés
- New vaccine introduction