Journal article
Challenges and responses in human vaccine development
Human vaccine development remains challenging because of the highly sophisticated evasion mechanisms of pathogens for which vaccines are not yet available. Recent years have witnessed both successes and failures of novel vaccine design and the strength of iterative approaches is increasingly appreciated. These combine discovery of novel antigens, adjuvants and vectors in the preclinical stage with computational analyses of clinical data to accelerate vaccine design. Reverse and structural vaccinology have revealed novel antigen candidates and molecular immunology has led to the formulation of promising adjuvants. Gene expression profiles and immune parameters in patients, vaccinees and healthy controls have formed the basis for biosignatures that will provide guidelines for future vaccine design.
Authors
Languages
- English
Publication year
2014
Journal
Current Opinion in Immunology
Volume
28
Type
Journal article
Categories
- Service delivery
Diseases
- HIV-AIDS
Tags
- New vaccine introduction